Three Cases of Methotrexate-associated Lymphoproliferative Disorder (MTX-LPD)
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چکیده
منابع مشابه
Large ulceration of the oropharynx induced by methotrexate-associated lymphoproliferative disorders.
We present a case of a 67-year-old Japanese man with a serious oropharyngeal ulceration that at first seemed to be destructive malignant lymphoma or oropharyngeal carcinoma. We suspected methotrexate (MTX)-associated lymphoproliferative disorder (LPD) induced by MTX treatment for rheumatoid arthritis (RA). About 3 weeks after simple discontinuation of MTX, complete regression of the disease was...
متن کاملMethotrexate-induced CD30+ T-cell lymphoproliferative disorder of the oral cavity
EBER: Epstein-Barr encoded RNA EBV: Epstein-Barr virus LPD: lymphoproliferative disorder MTX: methotrexate RA: rheumatoid arthritis INTRODUCTION For more than 30 years, methotrexate (MTX) has been a mainstay in the treatment of various inflammatory disorders including rheumatoid arthritis (RA) and psoriasis. Off-label use of MTX has expanded in recent years, as it is found to be effective in tr...
متن کاملTreatment of methotrexate (MTX) intolerance: behavioural therapy, versus switch to parenteral MTX versus oral MTX
Methods 45 JIA patients with MTX intolerance were randomised to receive oral MTX with anti-emetics (standard of care), parenteral MTX or oral MTX with behavioural therapy. Primary outcome was the occurrence of MTX intolerance, defined as ≥5 points on a validated MISS questionnaire, after a 3-month intervention period. Secondary outcome measures were: MTX intolerance after 6 and 12 months and th...
متن کاملOral Methotrexate-related Lymphoproliferative Disease Presenting with Severe Osteonecrosis of the Jaw: A Case Report and Literature Review
Long-term methotrexate (MTX) treatment can cause MTX-related lymphoproliferative disorder (MTX-LPD). We experienced a case of MTX-LPD that was associated with severe osteonecrosis of the jaw mimicking medication-related osteonecrosis of the jaw. The patient was an 81-year-old woman with rheumatoid arthritis (RA) who was treated with MTX and bisphosphonate. After 7 years, she was referred to our...
متن کامل[Methotrexate-associated lymphoproliferative disorder presenting as oral ulcers in a patient with rheumatoid arthritis].
Methotrexate-associated lymphoproliferative disorders are a heterogeneous group of lymphoid proliferations or lymphomas that develop in patients with autoimmune diseases treated using methotrexate. These lymphoproliferative disorders are often associated with Epstein-Barr virus infection and occasionally regress after the withdrawal of methotrexate therapy. The lymphoproliferative disorder in t...
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ژورنال
عنوان ژورنال: Nippon Jibiinkoka Gakkai Kaiho
سال: 2008
ISSN: 0030-6622,1883-0854
DOI: 10.3950/jibiinkoka.111.594